Affiliation:
1. Department of Engineering Department of Nanopharmaceutical Sciences Nagoya Institute of Technology, Gokiso, Showa-ku Nagoya 466-8555 Japan
2. CNRS UMR 6014 COBRA – Normandie Université 76821 Mont Saint Aignan France
Abstract
AbstractFrom 2000, our two research groups independently and simultaneously designed and developed a novel family of electrophilic fluorinating reagents based on the use of Cinchona alkaloids. The chiral N‐fluoro ammonium salts demonstrated the highest efficiency compared to prior art in enantioselective electrophilic fluorination for a wide range of substrates. In this account, we tell our respective stories, how the same idea germinated in our laboratories, the characterization of the chiral reagents, the use in stoichiometric quantity then the development of a catalytic version, the application to the synthesis of chiral fluorinated molecules of pharmaceutical interest, and finally the exploitation of our reagents by other teams and for other applications.
Funder
Nagoya Institute of Technology
Subject
Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry
Cited by
1 articles.
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