Unveiling the interplay between homogeneous and heterogeneous catalytic mechanisms in copper–iron nanoparticles working under chemically relevant tumour conditions

Author:

Bonet-Aleta Javier123ORCID,Encinas-Gimenez Miguel123ORCID,Urriolabeitia Esteban4ORCID,Martin-Duque Pilar2567ORCID,Hueso Jose L.1236ORCID,Santamaria Jesus1236ORCID

Affiliation:

1. Institute of Nanoscience and Materials of Aragon (INMA), CSIC-Universidad de Zaragoza, Campus Río Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, 50018, Zaragoza, Spain

2. Networking Research Center in Biomaterials, Bioengineering and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029, Madrid, Spain

3. Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Rio Ebro, C/María de Luna, 3, 50018 Zaragoza, Spain

4. Instituto de Síntesis Química y Catálisis Homogénea, ISQCH (CSIC-Universidad de Zaragoza), 50009 Zaragoza, Spain

5. Instituto Aragonés de Ciencias de la Salud (IACS), Avenida San Juan Bosco, 13, 50009 Zaragoza, Spain

6. Instituto de Investigación Sanitaria (IIS) Aragón, Avenida San Juan Bosco, 13, 50009 Zaragoza, Spain

7. Fundación Araid, Av. de Ranillas 1-D, 50018 Zaragoza, Spain

Abstract

This work studies in depth the interplay between glutathione (GSH) and a copper–iron oxide nanocatalyst. We describe the activation and interplay of homogeneous and heterogeneous processes that induce a cascade of reactions against cancer cells.

Funder

H2020 European Research Council

Gobierno de Aragón

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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