Recent developments in the enzymatic modifications of steroid scaffolds-Reference-Cited by-同舟云学术

Recent developments in the enzymatic modifications of steroid scaffolds

Published:2024 Issue:18 Volume:22 Page:3559-3583
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Huibin¹^ORCID,Abe Ikuro¹²^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

2. Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan

Abstract

This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.

Funder

Japan Society for the Promotion of Science

New Energy and Industrial Technology Development Organization

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00327F

Reference231 articles.

1. Microbial biotransformation of bioactive and clinically useful steroids and some salient features of steroids and biotransformation

2. Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs

3. Fluorination methods in drug discovery

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