Zirconium oxide nano-catalyzed synthesis of pharmacologically important bis(indolyl)methanes: a highly efficient and mild approach

Author:

Rathi Komal1ORCID,Tiwari Om Shanker2ORCID,Rawat Varun3ORCID,Jat Jawahar L.4ORCID,Yadav Dinesh Kumar5,Verma Ved Prakash16ORCID

Affiliation:

1. Department of Chemistry, Banasthali University, Banasthali Newai-304022, India

2. The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv-6997801, Israel

3. Faculty of Exact Sciences, Tel Aviv University, Tel Aviv-6997801, Israel

4. Department of Chemistry, Babasaheb Bhimrao Ambedkar University (A Central University) Vidya Vihar, Raebareli Road, Lucknow-226025, Uttar Pradesh, India

5. Department of Chemistry, Mohanlal Sukhadia University, Udaipur, 313001, India

6. Department of Education in Science and Mathematics (DESM), Regional Institute of Education, Bhubaneshwar, India

Abstract

A straightforward, highly efficient, and mild approach for synthesizing bis(indolyl)methanes (26 examples) is reported. The condensation between various aldehydes and indole is facilitated by ZrO2 nanoparticles (ZO-nps) as a catalyst in acetonitrile.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

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