Assessment of coulometric array electrochemical detection coupled with HPLC-UV for the absolute quantitation of pharmaceuticals

Author:

Hicks Michael B.12345ORCID,Salituro Leah12345,Mangion Ian12345,Schafer Wes12345,Xiang Rong12345,Gong Xiaoyi12345,Welch Christopher J.12345

Affiliation:

1. Department of Process & Analytical Chemistry

2. Merck & Co.

3. Inc.

4. Rahway

5. USA

Abstract

A novel approach for the absolute quantitation of pharmaceuticals without standards using a flow-through coulometric array detector and the known electrochemical redox conversion applying Faraday's law,Q=N/Fn.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference37 articles.

1. Electrochemical generation of drug metabolites with applications in drug discovery and development

2. R. J. Flanagan , D.Perrett and R.WhelptonThe Electrochemical Detector, in Electrochemical detection in HPLC:analysis of drugs and poisons, ed. R. M. Smith, 2005, RSC Chromatography Monographs, pp. 21–55

3. Electrochemical Behavior of Biologically Important Indole Derivatives

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