Ni(ii), Cu(ii) and Zn(ii) complexes with the 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for cancer therapy-Reference-Cited by-同舟云学术

Ni(ii), Cu(ii) and Zn(ii) complexes with the 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for cancer therapy

Published:2021 Issue:9 Volume:8 Page:2225-2247
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Liao Lan-Shan¹²³⁴⁵,Chen Yin¹²³⁴⁵,Mo Zu-Yu¹²³⁴⁵,Hou Cheng¹²³⁴⁵^ORCID,Su Gui-Fa¹²³⁴⁵^ORCID,Liang Hong¹²³⁴⁵,Chen Zhen-Feng¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmacy

3. Guangxi Normal University

4. Guilin 541004

5. China

Abstract

Complexes 1–3 display potent anticancer activity against T-24 cell by disrupting mitochondria and microtubules. Furthermore, complex 1 exhibits almost same tumor growth inhibition activity in T-24 xenograft mouse model as cisplatin and paclitaxel.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QI/D0QI01463J

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