Ni(ii), Cu(ii) and Zn(ii) complexes with the 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for cancer therapy
Author:
Affiliation:
1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources
2. School of Chemistry and Pharmacy
3. Guangxi Normal University
4. Guilin 541004
5. China
Abstract
Complexes 1–3 display potent anticancer activity against T-24 cell by disrupting mitochondria and microtubules. Furthermore, complex 1 exhibits almost same tumor growth inhibition activity in T-24 xenograft mouse model as cisplatin and paclitaxel.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangxi Province
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/QI/D0QI01463J
Reference86 articles.
1. In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands
2. Direct Cellular Responses to Platinum-Induced DNA Damage
3. Cancer nanomedicine: progress, challenges and opportunities
4. Methotrexate–Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy
5. 7-Aroyl-aminoindoline-1-sulfonamides as a Novel Class of Potent Antitubulin Agents
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