1. Institute of Cancer Research, National Health Research Institutes, Taipei, Taiwan, Republic of China, Divison of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan, Republic of China, and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China