The stereoselective synthesis of <i>cis</i>- and <i>trans</i>-fused pyrrolidine containing bicyclic azepine and oxepine derivatives using aza-Cope rearrangement-Mannich cyclization as a key step-Reference-Cited by-同舟云学术

The stereoselective synthesis of cis- and trans-fused pyrrolidine containing bicyclic azepine and oxepine derivatives using aza-Cope rearrangement-Mannich cyclization as a key step

Published:2022 Issue:45 Volume:46 Page:21930-21941
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Lukyanenko Evgeny R.¹,Belov Grigory M.¹,Novoselov Anton M.¹,Nechaev Mikhail S.¹²^ORCID,Kurkin Alexander V.¹^ORCID

Affiliation:

1. Department of Chemistry, Lomonosov Moscow State University, 1/3 Leninsky Gory, Moscow 119991, Russia

2. A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect 29, Moscow, Russian Federation

Abstract

The development of novel methods and strategies for the formation of fused five-, six-, and seven-membered ring structures is of utmost importance in organic syntheses.

Funder

Russian Foundation for Basic Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ03936B

Reference36 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Can the pharmaceutical industry reduce attrition rates?

3. Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

4. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

5. Inhibitors of the p53/hdm2 protein–protein interaction—path to the clinic

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