Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
Author:
Affiliation:
1. Discovery Chemistry, ‡Discovery Oncology, §Discovery Technologies, ∥Non-Clinical Development, Roche Research Center, Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, New Jersey 07110, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml4000657
Reference25 articles.
1. The p53 pathway: positive and negative feedback loops
2. Surfing the p53 network
3. p53, the Cellular Gatekeeper for Growth and Division
4. p53 and Human Cancer: The First Ten Thousand Mutations
5. Functions of the MDM2 oncoprotein
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