Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD–ACE2 and TMPRRS2 proteins

Author:

Shayo Mariana J.1ORCID,Samwel Baraka2,Shadrack Daniel M.34,Cassel Joel5ORCID,Salvino Joseph M.5ORCID,Montaner Luis J.5ORCID,Deogratias Geradius6ORCID,Tietjen Ian5,Kiruri Lucy7,Hilonga Samson8,Innocent Ester1

Affiliation:

1. Department of Biological and Pre-clinical Studies, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O.Box 65001, Dar es Salaam, Tanzania

2. Department of Natural Products, Institute of Traditional Medicines, Muhimbili University of Health and Allied Sciences, P.O.Box 65001, Dar es Salaam, Tanzania

3. Department of Chemistry, Faculty of Natural and Applied Sciences, St. John's University of Tanzania, P.O.Box 47, Dodoma, Tanzania

4. School of Life Science and Bio-engineering, Nelson Mandela African Institute of Science and Technology, P.O.Box 447, Arusha, Tanzania

5. The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA

6. Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O.Box 35061, Dar es Salaam, Tanzania

7. Kenyata University, Department of Chemistry, P.O.Box 43844-00100, Nairobi, Kenya

8. Department of Medical Botany, Plant Breeding and Agronomy, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O.Box 65001, Dar es Salaam, Tanzania

Abstract

The coronavirus disease 2019 (COVID-19) has spread worldwide with severe health, social, and economic repercussions.

Funder

Styrelsen för Internationellt Utvecklingssamarbete

Philadelphia Foundation

Canadian Institutes of Health Research

African-German Network of Excellence in Science

Publisher

Royal Society of Chemistry (RSC)

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