A synthetic route to 1,4-disubstituted tetrahydro-β-carbolines and tetrahydropyranoindoles via ring-opening/Pictet–Spengler reaction of aziridines and epoxides with indoles/aldehydes-Reference-Cited by-同舟云学术

A synthetic route to 1,4-disubstituted tetrahydro-β-carbolines and tetrahydropyranoindoles via ring-opening/Pictet–Spengler reaction of aziridines and epoxides with indoles/aldehydes

Published:2020 Issue:2 Volume:18 Page:272-287
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wani Imtiyaz Ahmad¹²³,Goswami Gaurav¹²³,Sk Sahid¹²³,Mal Abhijit¹²³,Sayyad Masthanvali¹²³,Ghorai Manas K.¹²³^ORCID

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology Kanpur

3. India

Abstract

A route to 1,4-disubstituted tetrahydro-β-carbolines and tetrahydropyrano[3,4-b]indoles in high yields and stereoselectivity via S_N2-type ring opening/Pictet–Spengler reaction of aziridines and epoxides with indoles is described.

Funder

Indian Institute of Technology Kanpur

Department of Science and Technology, Ministry of Science and Technology

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02098E

Reference101 articles.

1. An Enantioselective Total Synthesis of (+)-Geissoschizine