Development of a selective ligand for G–G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure-Reference-Cited by-同舟云学术

Development of a selective ligand for G–G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure

Published:2022 Issue:16 Volume:20 Page:3375-3381
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Murase Hirotaka¹^ORCID,Nagatsugi Fumi²^ORCID,Sasaki Shigeki¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis ten bosch machi, Sasebo 859-3298, Japan

2. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan

Abstract

A small-molecular G-clamp ligand that converts the G-quadruplex of CGG repeats to a hairpin form has been developed.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00279E

Reference27 articles.

1. Expandable DNA repeats and human disease

2. Repeat instability: mechanisms of dynamic mutations

3. Repeat expansion disease: progress and puzzles in disease pathogenesis

4. CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

5. RAN Translation: Fragile X in the Running

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