Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis-Reference-Cited by-同舟云学术

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Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

Published:2018 Issue:8 Volume:35 Page:735-756
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Rabe Patrick¹²³⁴⁵^ORCID,Kamps Jos J. A. G.¹²³⁴⁵^ORCID,Schofield Christopher J.¹²³⁴⁵^ORCID,Lohans Christopher T.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Chemistry Research Laboratory

3. University of Oxford

4. Oxford

5. UK

Abstract

The 2OG oxygenases and IPNS contribute to the great structural diversity of β-lactam natural products, employing some remarkable mechanisms.

Funder

Wellcome Trust

Medical Research Council

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NP/C8NP00002F

Reference189 articles.

1. The antibiotics market

2. Origins of the β-lactam rings in natural products

3. β-Lactams and β-Lactamase Inhibitors: An Overview

4. The enzymes of β-lactam biosynthesis

5. What's new in antibiotic resistance? Focus on beta-lactamases

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