High-throughput drug target discovery using a fully automated proteomics sample preparation platform-Reference-Cited by-同舟云学术

High-throughput drug target discovery using a fully automated proteomics sample preparation platform

Published:2024 Issue:8 Volume:15 Page:2833-2847
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wu Qiong¹^ORCID,Zheng Jiangnan¹²^ORCID,Sui Xintong¹,Fu Changying¹,Cui Xiaozhen¹,Liao Bin¹,Ji Hongchao¹^ORCID,Luo Yang¹,He An¹,Lu Xue¹,Xue Xinyue¹^ORCID,Tan Chris Soon Heng¹³²^ORCID,Tian Ruijun¹³²^ORCID

Affiliation:

1. Department of Chemistry, School of Science, Southern University of Science and Technology, Shenzhen 518055, China

2. Southern University of Science and Technology, Guangming Advanced Research Institute, Shenzhen 518055, China

3. Research Center for Chemical Biology and Omics Analysis, School of Science, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen 518055, China

Abstract

We developed a fully automated proteomics sample preparation platform and a high-throughput drug target discovery workflow, achieving 10 times higher throughput than thermal proteome profiling.

Funder

National Natural Science Foundation of China

Shenzhen Municipal Science and Technology Innovation Council

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05937E

Reference43 articles.

1. Predictive validity in drug discovery: what it is, why it matters and how to improve it

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5. A proteome-wide atlas of drug mechanism of action

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