Predictive validity in drug discovery: what it is, why it matters and how to improve it-Reference-Cited by-同舟云学术

Predictive validity in drug discovery: what it is, why it matters and how to improve it

Published:2022-10-04 Issue:12 Volume:21 Page:915-931
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

Scannell Jack W.^ORCID,Bosley James,Hickman John A.^ORCID,Dawson Gerard R.^ORCID,Truebel Hubert^ORCID,Ferreira Guilherme S.^ORCID,Richards Duncan^ORCID,Treherne J. Mark^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.nature.com/articles/s41573-022-00552-x.pdf

Reference280 articles.

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3. Cook, D. et al. Lessons learned from the fate of AstraZeneca’s drug pipeline: a five-dimensional framework. Nat. Rev. Drug Discov. 13, 419–431 (2014).

4. Emmerich, C. H. et al. Improving target assessment in biomedical research: the GOT-IT recommendations. Nat. Rev. Drug Discov. 20, 64–81 (2021).

5. Edwards, A. M. et al. Preclinical target validation using patient-derived cells. Nat. Rev. Drug Discov. 14, 149–150 (2015).

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