Stereoselective synthesis of tri-substituted tetrahydrothiophenes and their <i>in silico</i> binding against mycobacterial protein tyrosine phosphatase B-Reference-Cited by-同舟云学术

Stereoselective synthesis of tri-substituted tetrahydrothiophenes and their in silico binding against mycobacterial protein tyrosine phosphatase B

Published:2022 Issue:15 Volume:20 Page:3124-3135
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jain Anshul¹,Maji Sushobhan²,Shukla Khyati³,Kumari Akanksha¹,Garg Shivani²,Metre Ramesh K.¹^ORCID,Bhattacharyya Sudipta²^ORCID,Rana Nirmal K.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Jodhpur, Rajashtan-342037, India

2. Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Rajashtan-342037, India

3. Department of Chemistry, Indian Institute of Technology Kanpur, Uttar Pradesh-208016, India

Abstract

DABCO catalysed highly diastereoselective cascade thia-Michael/aldol reaction was established for the construction of diversely functionalized tetrahydrothiophenes. Their in silico structure–function activities against MptpB have also been studied.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Indian Institute of Technology Jodhpur

Ministry of Education, India

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00052K

Reference62 articles.