Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo-Reference-Cited by-同舟云学术

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

Published:2018-08-28 Issue:18 Volume:61 Page:8337-8352
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vickers Clare F.¹,Silva Ana P. G.²,Chakraborty Ajanta²,Fernandez Paulina²,Kurepina Natalia³,Saville Charis²,Naranjo Yandi⁴,Pons Miquel⁴^ORCID,Schnettger Laura S.⁵,Gutierrez Maximiliano G.⁵,Park Steven³,Kreiswith Barry N.³,Perlin David S.³,Thomas Eric J.¹,Cavet Jennifer S.²,Tabernero Lydia²^ORCID

Affiliation:

1. The School of Chemistry, University of Manchester, Manchester M13 9PL, United Kingdom

2. School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom

3. Public Health Research Institute, New Jersey Medical School, Rutgers University, 225 Warren Street, Newark, New Jersey 07103, United States

4. Departament de Química Inorgànica i Orgànica, Universitat de Barcelona, Baldiri Reixac, 10-12, 08028 Barcelona, Spain

5. Host−Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, United Kingdom

Funder

Medical Research Council

Francis Crick Institute

Ministerio de Econom?a y Competitividad

Ag?ncia de Gesti? d?Ajuts Universitaris i de Recerca

National Institute of Allergy and Infectious Diseases

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Cancer Research UK