One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction-Reference-Cited by-同舟云学术

One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction

Published:2021 Issue:19 Volume:57 Page:2388-2391
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hyun Soonsil¹²³⁴^ORCID,Park Namjoon⁵²³⁴,Nam So Hee⁶²³⁴,Cheon Dae Hee⁶²³⁴,Lee Yan⁶²³⁴^ORCID,Lim Hyun-Suk⁶⁷⁸⁴^ORCID,Yu Jaehoon⁵²³⁴^ORCID

Affiliation:

1. The Institute of Molecular Biology & Genetics

2. Seoul National University

3. Seoul 08826

4. Korea

5. Department of Chemistry & Education

6. Department of Chemistry

7. Pohang University of Science and Technology

8. Pohang 37673

Abstract

The novel cyclic peptoid I11, identified from the OBOC library, promotes recovery of damaged mitochondria via binding to CypD, rejuvenating mitochondrial function without toxicity.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC08268F

Reference28 articles.

1. Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

2. Methods for generating and screening libraries of genetically encoded cyclic peptides in drug discovery

3. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

4. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

5. Cyclophilin A: a key player for human disease

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