The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates-Reference-Cited by-同舟云学术

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The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates

Published:2019 Issue:20 Volume:10 Page:5197-5210
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Klahn Philipp¹²³⁴⁵^ORCID,Fetz Verena¹²³⁴,Ritter Antje¹²³⁴,Collisi Wera¹²³⁴⁶,Hinkelmann Bettina¹²³⁴,Arnold Tatjana¹²³⁴,Tegge Werner¹²³⁴,Rox Katharina¹²³⁴⁷,Hüttel Stephan⁶²³⁴^ORCID,Mohr Kathrin I.⁶²³⁴,Wink Joachim⁶²³⁴,Stadler Marc⁶²³⁴^ORCID,Wissing Josef⁸⁹²³⁴,Jänsch Lothar⁸⁹²³⁴,Brönstrup Mark¹²³⁴¹⁰^ORCID

Affiliation:

1. Department of Chemical Biology

2. Helmholtz Centre for Infection Research

3. 38124 Braunschweig

4. Germany

5. Institute of Organic Chemistry

6. Department of Microbial Drugs

7. German Centre of Infection Research (DZIF)

8. Department of Structure and Function of Proteins

9. Research Group Cellular Proteomic

10. Biomolecular Drug Research Center (BMWZ)

Abstract

Ratjadone derivatives have been successfully introduced as suitable payloads with new mode of action for targeted drug conjugates.

Funder

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC05542D

Reference86 articles.

1. Antibody–drug conjugates: Basic concepts, examples and future perspectives

2. Advances in Anticancer Antibody-Drug Conjugates and Immunotoxins

3. Site-specific antibody drug conjugates for cancer therapy

4. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

5. Antibody–drug conjugates for cancer therapy

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