Design of non-cytotoxic 6,7-dihydroxycoumarin-5-carboxylates with antibiofilm activity against <i>Staphylococcus aureus</i> and <i>Candida albicans</i>-Reference-Cited by-同舟云学术

Design of non-cytotoxic 6,7-dihydroxycoumarin-5-carboxylates with antibiofilm activity against Staphylococcus aureus and Candida albicans

Published:2023 Issue:23 Volume:21 Page:4744-4749
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zscherp Robert¹²,Chakrabarti Aishi³⁴^ORCID,Lehmann Anna P.¹²^ORCID,Schrey Hedda⁵⁶,Zeng Hoaxuan⁵⁶,Collisi Wera⁵⁶,Klahn Philipp²³⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany

2. Laboratories of Natural Product and Conjugation Chemistry (naconLabs) – A Technology Transfer Center of iTUBS mbH, Wilhelmsgarten 3, 38100 Braunschweig, Germany

3. Division of Organic and Medicinal Chemistry, Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården 4, 41296 Göteborg, Sweden

4. Centre for Antibiotic Resistance Research in Gothenburg (CARe), Sweden

5. Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany

6. German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany

Abstract

A five-step synthesis of DHCou and 4-MeDHCou is reported. Both compounds retain the antibiofilm activity of the parent Esculetin and 4-Methylesculetin against biofilms of S. aureus and C. albicans but lacking their cytotoxicity.

Funder

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Deutsche Forschungsgemeinschaft

Fonds der Chemischen Industrie

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00303E

Reference53 articles.

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