Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature

Author:

Singh Shweta1,Popuri Sureshbabu1,Junaid Qazi Mohammad2,Sabiah Shahulhameed2,Kandasamy Jeyakumar1ORCID

Affiliation:

1. Department of chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh-221005, India

2. Department of Chemistry, Pondicherry University, Pondicherry-605014, India

Abstract

A wide range of N-tosyl α-ketoamides underwent transamidation with various alkyl and benzyl amines in the absence of a catalyst or base at room temperature. On the other hand, transamidation in N-Boc α-ketoamides was achieved in the presence of Cs2CO3.

Funder

Indian Institute of Technology (BHU) Varanasi

Science and Engineering Research Board

Max-Planck-Gesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference85 articles.

1. A.Greenberg , C. M.Breneman and J. F.Liebman , The Amide Linkage: Structural Significance in Chemistry, Biochemistry, and Materials Science , Wiley-Interscience , New York , 2000

2. Amide activation: an emerging tool for chemoselective synthesis

3. Rethinking amide bond synthesis

4. Nonclassical Routes for Amide Bond Formation

5. Efficient Transamidation of Primary Carboxamides by in Situ Activation with N,N-Dialkylformamide Dimethyl Acetals

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