Syntheses of α-CF3-α-quaternary ketones via p-quinone methides and their derivatization to compounds with successively congested stereogenic centers-Reference-Cited by-同舟云学术

Syntheses of α-CF3-α-quaternary ketones via p-quinone methides and their derivatization to compounds with successively congested stereogenic centers

Published:2020 Issue:24 Volume:18 Page:4638-4644
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Terashima Kyu¹²³⁴⁵,Kawasaki-Takasuka Tomoko¹²³⁴⁵,Agou Tomohiro⁶⁷⁸⁵^ORCID,Kubota Toshio⁶⁷⁸⁵,Yamazaki Takashi¹²³⁴⁵^ORCID

Affiliation:

1. Division of Applied Chemistry

2. Institute of Engineering

3. Tokyo University of Agriculture and Technology

4. Koganei 184-8588

5. Japan

6. Department of Biomolecular Functional Engineering

7. Ibaraki University

8. Hitachi 316-8511

Abstract

NHC-catalyzed 1,6-conjugate additions of a variety of aldehydes to δ-CF₃-δ-substituted p-quinone methides and their highly diastereoselective derivatization to compounds with successively congested stereogenic centers were performed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00951B

Reference54 articles.

1. Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

2. Enantioselective Formation of CF3-Bearing All-Carbon Quaternary Stereocenters via C–H Functionalization of Methanol: Iridium Catalyzed Allene Hydrohydroxymethylation

3. Visible Light-Induced Radical Cyclization of Tertiary Bromides with Isonitriles To Construct Trifluoromethylated Quaternary Carbon Center

4. Taming Radical Intermediates for the Construction of Enantioenriched Trifluoromethylated Quaternary Carbon Centers

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