Affiliation:
1. Department of Chemistry National Tsing Hua University Hsinchu, R. O. C. Taiwan
2. Department of Chemistry National Cheng Kung University Tainan, R.O.C. Taiwan
Abstract
AbstractA simple visible‐light‐induced CuCl‐catalyzed synthesis was developed for highly functionalized carbon‐centered compounds (α‐alk/aryloxy‐α‐diaryl/alkylaryl‐acetaldehydes/ketones) at room temperature using benzoquinone, alkyl/aryl alcohol, and alkyl/aryl terminal/internal alkynes. Late‐stage functionalized compounds show good antifungal activities, especially againstCandida kruseifungal strain, in in vitro experiments (the Broth microdilution method). Moreover, toxicity tests (zebrafish egg model experiments) indicated that these compounds had negligible cytotoxicity. The green chemistry metrics (E‐factor value is 7.3) and eco‐scale (eco‐scale value is 58.8) evaluations show that the method is simple, mild, highly efficient, eco‐friendly, and environmentally feasible.
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
3 articles.
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