The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides-Reference-Cited by-同舟云学术

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

Published:2022 Issue:4 Volume:3 Page:426-430
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Pham Truc Lam¹²^ORCID,Zilke Jennifer¹²^ORCID,Müller Christine Charlotte³^ORCID,Thomas Franziska¹²^ORCID

Affiliation:

1. Institute of Organic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany

2. Centre for Advanced Materials, Heidelberg University, Im Neuenheimer Feld 225, 69120 Heidelberg, Germany

3. Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1a, 52074 Aachen, Germany

Abstract

Difficult peptide sequences can be synthesized in high quality by combining the polar CSY aspartate protecting group and selective microwave irradiation.

Funder

Verband der Chemischen Industrie

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00252J

Reference20 articles.

1. ChemMatrix, a Poly(ethylene glycol)-Based Support for the Solid-Phase Synthesis of Complex Peptides

2. High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS)

3. Microwave heating in solid-phase peptide synthesis

4. Aspartimide formation in peptide chemistry: occurrence, prevention strategies and the role of N-hydroxylamines

5. Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis

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