Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner-Reference-Cited by-同舟云学术

Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner

Published:2021 Issue:38 Volume:57 Page:4678-4681
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Napoleon John V.¹²³,Singh Sarbjit¹²³,Rana Sandeep¹²³,Bendjennat Mourad¹²³,Kumar Vikas⁴³,Kizhake Smitha¹²³,Palermo Nicholas Y.⁴³⁵²³,Ouellette Michel M.⁶⁷²³⁸,Huxford Tom⁹¹⁰¹¹¹²³^ORCID,Natarajan Amarnath¹²³⁸¹³^ORCID

Affiliation:

1. Eppley Institute for Research in Cancer and Allied Diseases

2. UNMC

3. USA

4. Mass Spectrometry and Proteomics Core Facility, UNMC

5. Computational Chemistry Core Facility

6. Division of Gastroenterology and Hepatology

7. Department of Internal Medicine

8. Fred & Pamela Buffett Cancer Center

9. Structural Biochemistry Laboratory

10. Department of Chemistry & Biochemistry

11. San Diego State University

12. San Diego

13. University of Nebraska Medical Center

Abstract

ATP non-competitive IKKβ inhibitor that allows for transient activation of the cannonical NF-κB pathway.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC01245B

Reference31 articles.

1. Overview of the use of the anti-TNF agent infliximab in chronic inflammatory diseases

2. IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

3. Introduction to NF-κB: players, pathways, perspectives

4. Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors

5. A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells

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