Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures-Reference-Cited by-同舟云学术

Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures

Published:2015 Issue:21 Volume:13 Page:5972-5982
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Konda Shyam K.¹²³⁴⁵,Wang Haiqiang¹²³⁴⁵,Cutts Suzanne M.⁶⁷⁸⁹,Phillips Don R.⁶⁷⁸⁹,Collins J. Grant¹²³⁴⁵

Affiliation:

1. School of Physical

2. Environmental and Mathematical Sciences

3. University of New South Wales

4. Australian Defence Force Academy

5. Campbell

6. Biochemistry Department

7. La Trobe University

8. Bundoora

9. Australia

Abstract

The anti-cancer drug pixantrone intercalates predominantly from the minor groove at adenine bulge sites, but with approximately equal frequency from the minor and major grooves at CpA sites.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00526D

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1. Bbr 2778, an Aza-anthracenedione Endowed with Preclinical Anticancer Activity and Lack of Delayed Cardiotoxicity

2. A clinical phase I and pharmacokinetic study of BBR 2778, a novel anthracenedione analogue, administered intravenously, 3 weekly

3. Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial

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