Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis

Author:

Lee Jungseub1,Jung Sangmin1ORCID,Hong Hye Kyoung23,Jo Hyeonsu1,Rhee Stephen1,Jeong Ye-Lin3,Ko Jihoon4ORCID,Cho Yong Beom256,Jeon Noo Li17ORCID

Affiliation:

1. Department of Mechanical Engineering, Seoul National University, Seoul, Republic of Korea

2. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

3. Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea

4. Department of Bionano Technology, Gachon University, Seoul, Republic of Korea

5. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea

6. Department of Biopharmaceutical Convergence, Sungkyunkwan University, Seoul, Republic of Korea

7. Institute of Advanced Machines and Design, Seoul National University, Seoul, Republic of Korea

Abstract

VT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug effects.

Funder

National Research Foundation of Korea

Institute for Information and Communications Technology Promotion

Gachon University

Publisher

Royal Society of Chemistry (RSC)

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1. Recapitulating the Cancer‐Immunity Cycle on a Chip;Advanced Healthcare Materials;2024-09-02

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