Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design-Reference-Cited by-同舟云学术

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Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design

Published:2021 Issue:31 Volume:11 Page:18938-18944
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lei Jia-Hong¹²³⁴⁵^ORCID,Ma Ling-Ling⁶⁷⁸²³,Xian Jing-Hong⁹¹⁰⁵¹¹,Chen Hai⁶⁷⁸²³,Zhou Jian-Jian¹²¹³¹¹,Chen Hao¹⁴¹⁵¹⁶¹⁷¹⁸,Lei Qian⁶⁷⁸²³,Li Yu-Yan¹²³⁴⁵,Wang Yan-Yan¹⁹²⁰³⁵¹¹,Wang Yu-Xi¹²³⁴⁵^ORCID

Affiliation:

1. Cancer Center

2. West China Hospital

3. Sichuan University

4. Collaborative Innovation Center of Biotherapy

5. Chengdu 610041

6. Targeted Tracer Research and Development Laboratory

7. Precision Medicine Research Center

8. Department of Respiratory and Critical Care Medicine

9. Department of Clinical Research

10. West China Hospital Sichuan University

11. P. R. China

12. Beijing Loham Co.,Limited

13. Beijing 100068

14. Department of Pharmaceutical Sciences

15. College of Pharmacy

16. University of Tennessee Health Science Center

17. Memphis

18. USA

19. West China National Clinical Research Center for Geriatrics

20. School of Nursing

Abstract

Crystal structures of tubulin complexed with ELR510444 and parbendazole facilitate the design of novel colchicine binding site inhibitors.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

West China Hospital, Sichuan University

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA01173A

Reference27 articles.

1. Structural Insights into Microtubule Function

2. Microtubule-binding agents: a dynamic field of cancer therapeutics

3. Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review

4. Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton

5. Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

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1. Structure-Based Optimization of Carbendazim-Derived Tubulin Polymerization Inhibitors through Alchemical Free Energy Calculations;Journal of Chemical Information and Modeling;2023-11-10

2. Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells;Pharmaceuticals;2023-07-13

3. Mechanism of action and side effects of colchicine based on biomechanical properties of cells;Journal of Microscopy;2023-07-12

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