Competitive profiling of ligandable cysteines in <i>Staphylococcus aureus</i> with an organogold compound-Reference-Cited by-同舟云学术

Competitive profiling of ligandable cysteines in Staphylococcus aureus with an organogold compound

Published:2022 Issue:36 Volume:58 Page:5526-5529
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Schmidt Claudia¹^ORCID,Zollo Michael²^ORCID,Bonsignore Riccardo¹³,Casini Angela¹^ORCID,Hacker Stephan M.²⁴^ORCID

Affiliation:

1. Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany

2. Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany

3. Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Università degli Studi di Palermo, Viale delle Scienze, Edificio 17, 90128 Palermo, Italy

4. Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

Abstract

With the idea of exploiting metal templated C–S bond forming reactions to achieve modification of cysteines in bacterial proteins, a cyclometalated Au(iii) compound was explored in a competitive chemoproteomic approach in S. aureus cell extracts.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01259F

Reference43 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

2. Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis

3. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

4. A Deep Learning Approach to Antibiotic Discovery

5. Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

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