Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting

Author:

Kudsiova Laila1234,Welser Katharina56784,Campbell Frederick56784,Mohammadi Atefeh56784,Dawson Natalie56784,Cui Lili1234,Hailes Helen C.56784,Lawrence M. Jayne1234,Tabor Alethea B.56784

Affiliation:

1. Institute of Pharmaceutical Science, King's College London

2. Franklin–Wilkins Building

3. London SE1 9NH

4. UK

5. Department of Chemistry

6. University College London

7. Christopher Ingold Laboratories

8. London WC1H 0AJ

Abstract

Ternary nanocomplexes, composed of bifunctional cationic peptides, lipids and siRNA, as delivery vehicles for siRNA have been investigated.

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

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