Understanding and optimising the transfection of lipopolyplexes formulated in saline: the effects of peptide and serum-Reference-Cited by-同舟云学术

Understanding and optimising the transfection of lipopolyplexes formulated in saline: the effects of peptide and serum

Published:2023 Issue:9 Volume:11 Page:3335-3353
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Cui Lili¹^ORCID,Kudsiova Laila¹,Campbell Frederick²,Barlow David J.³^ORCID,Hailes Helen C.²^ORCID,Tabor Alethea B.²^ORCID,Lawrence M. Jayne¹³^ORCID

Affiliation:

1. Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, Waterloo Campus, London SE1 9NH, UK

2. Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H 0AJ, UK

3. Division of Pharmacy & Optometry, School of Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK

Abstract

Lipopolyplexes formulated from branched cationic peptides with cell receptor targeting sequences, DOTMA and DOPE, and plasmid DNA in the presence of saline form multilamellar nanoparticles with enhanced stability and transfection in serum.

Funder

National Science Foundation

Horizon 2020 Framework Programme

Engineering and Physical Sciences Research Council

King's College London

Science and Technology Facilities Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01905A

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