Second derivative synchronous fluorescence determination of avanafil in the presence of its acid-induced degradation product aided by powerful Lean Six Sigma tools augmented with D-optimal design-Reference-Cited by-同舟云学术

Second derivative synchronous fluorescence determination of avanafil in the presence of its acid-induced degradation product aided by powerful Lean Six Sigma tools augmented with D-optimal design

Published:2021 Issue:7 Volume:11 Page:3834-3842
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Attia Khalid A. M.¹²³⁴⁵,Mohamad Ahmad A.¹²³⁴⁵,Emara Mohamed S.¹²³⁴⁵^ORCID,Abdel-Raoof Ahmed M.¹²³⁴⁵^ORCID,Hasan Mohamed A.¹²³⁴⁵^ORCID,Madkour Ahmed W.¹²³⁴⁵,El-Desouky Ebrahim A.¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Analytical Chemistry Dept.

2. Faculty of Pharmacy

3. Al-Azhar University

4. Cairo 11751

5. Egypt

Abstract

In this work, the quantitative determination of an erectile dysfunctional drug avanafil in the presence of its acid-induced degradation product was achieved via the application of a pre-optimized novel spectrofluorimetric method.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA08216C

Reference39 articles.

1. Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction

2. A Randomized, Double‐Blind, Placebo‐Controlled Evaluation of the Safety and Efficacy of Avanafil in Subjects with Erectile Dysfunction

3. Efficacy and safety of avanafil for treating erectile dysfunction: results of a multicentre, randomized, double-blind, placebo-controlled trial

4. Avanafil for the Treatment of Erectile Dysfunction: A Multicenter, Randomized, Double-Blind Study in Men With Diabetes Mellitus

5. An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction

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