A biomimetic renal fibrosis progression model on-chip evaluates anti-fibrotic effects longitudinally in a dynamic fibrogenic niche

Author:

Wu Di123,Wu Jianguo1,Liu Hui145,Shi Shengyu1,Wang Liangwen6,Huang Yixiao45,Yu Xiaorui45,Lei Zhuoyue45,Ouyang Tanliang45,Shen Jia7,Wu Guohua243,Wang Shuqi1453ORCID

Affiliation:

1. Institute for Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, 310029, China

2. Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China

3. Tianfu Jincheng Laboratory, City of Future Medicine, Chengdu, 641400, China

4. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610065, China

5. Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610065, China

6. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

7. Kidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310029, China

Abstract

A biomimetic renal fibrosis progression on-chip reveals the dynamic interplay between fibroblasts and kidney-derived extracellular matrix (ECM) and enables the assessment of anti-fibrosis efficacy at different fibrotic stages.

Funder

National Key Research and Development Program of China

National Key Scientific Instrument and Equipment Development Projects of China

West China Hospital, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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