DLM–GelMA/tumor slice sandwich structured tumor on a chip for drug efficacy testing

Author:

Hu Wenqi1234,Bei Ho-Pan5,Jiang Hongwei6,Wu Di1234,Yu Xiaorui1234,Zhou Xintong5ORCID,Sun Qiuwan7,Lu Qinrui7,Du Qijun1234,Wang Liangwen8,Luo Zhi9,Wu Guohua6,Zhao Xin510ORCID,Wang Shuqi1234ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine, Provincial Clinical Research Center for Respiratory Diseases, West China Hospital, Sichuan University, Chengdu, 610065, People's Republic of China

2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610065, China

3. College of Biomedical Engineering, Sichuan University, Chengdu, 610065, China

4. Tianfu Jincheng Laboratory, City of Future Medicine, Chengdu, 641400, China

5. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, 999077, China

6. Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China

7. Sichuan Diya BioTechnology Group Company, Chengdu, 641400, China

8. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

9. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China

10. Research Institute for Intelligent Wearable Systems, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, China

Abstract

DLM–GelMA sandwich structure tumor slice-on-a-chip could faithfully reflect the tumor microenvironment and immune response for drug efficacy screening.

Funder

National Key Research and Development Program of China

West China Hospital, Sichuan University

Hong Kong Polytechnic University

Publisher

Royal Society of Chemistry (RSC)

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