Tailored mechanosensitive nanogels release drugs upon exposure to different levels of stenosis

Author:

Kimna Ceren12,Miller Naranjo Bernardo12,Eckert Franziska12,Fan Di12,Arcuti Dario3,Mela Petra3,Lieleg Oliver12ORCID

Affiliation:

1. School of Engineering and Design, Department of Materials Engineering, Technical University of Munich, Boltzmannstraße 15, 85748 Garching, Germany

2. Center for Protein Assemblies (CPA) and Munich Institute of Biomedical Engineering, Technical University of Munich, Ernst-Otto-Fischer Straße 8, 85748, Garching, Germany

3. Medical Materials and Implants, Department of Mechanical Engineering and Munich Institute of Biomedical Engineering, TUM School of Engineering and Design, Technical University of Munich, Boltzmannstraße 15, 85748, Garching, Germany

Abstract

Nanogels with tunable stiffness were developed to address different stenosis levels. Those hemocompatible nanogels can release loaded drugs when passing a stenotic constriction, thus, delivering, e.g., anticoagulant drugs, exactly when needed.

Funder

Bundesministerium für Bildung und Forschung

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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