Affiliation:
1. Shanghai Engineering Research Center of Organ Repair School of Medicine Shanghai University Shanghai 200444 China
2. Weihai Medical Area 970 Hospital of Joint Logistic Support Force of PLA Weihai 264200 China
3. Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences St. John's University New York 11439 USA
Abstract
AbstractAtherosclerosis, the leading cause of death worldwide, is responsible for ≈17.6 million deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery efficiencies and significant side effects, and this has hampered the development of effective treatment strategies. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle‐mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery. The content of this study reveals the potential and challenges of nanoparticle use for the treatment of atherosclerosis and highlights new effective design ideas.
Funder
Natural Science Foundation of Shanghai Municipality
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)