A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine-Reference-Cited by-同舟云学术

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A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine

Published:2015 Issue:2 Volume:11 Page:463-474
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Gu Shenghua¹²³⁴⁵,Cao Bei¹²³⁴⁵,Sun Runbin¹²³⁴⁵,Tang Yueqing⁶⁷⁸⁹,Paletta Janice L.¹⁰¹¹⁹,Wu Xiao-Lei⁶⁷⁸⁹,Liu Linsheng¹²³⁴⁵,Zha Weibin¹²³⁴⁵,Zhao Chunyan¹²³⁴⁵,Li Yan⁶⁷⁸⁹,Radlon Jason M.¹²¹³¹⁴¹⁵,Hylemon Phillip B.¹²¹³¹⁴¹⁵,Zhou Huiping¹²¹³¹⁴¹⁵,Aa Jiye¹²³⁴⁵,Wang Guangji¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Key Laboratory of Drug Metabolism and Pharmacokinetics

3. Jiangsu Key laboratory of drug design and optimization

4. China Pharmaceutical University

5. Nanjing 210009

6. College of Engineering

7. Peking University

8. Beijing 100871

9. China

10. Center for Drug Safety Evaluation and Research

11. Shanghai University of Traditional Chinese Medicine

12. Department of Microbiology & Immunology

13. Virginia Commonwealth University

14. Richmond

15. USA

Abstract

The turnover of bile acids was involved in the lipid lowering effect of orally administered berberine.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C4MB00500G

Reference49 articles.

1. Bacteria-Induced Intestinal Cancer in Mice with Disrupted Gpx1 and Gpx2 Genes

2. Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding

3. The anti-inflammatory potential of berberine in vitro and in vivo

4. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters

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