New insights into the stereospecific reduction by an (S) specific carbonyl reductase from Candida parapsilosis ATCC 7330: experimental and QM/MM studies-Reference-Cited by-同舟云学术

New insights into the stereospecific reduction by an (S) specific carbonyl reductase from Candida parapsilosis ATCC 7330: experimental and QM/MM studies

Published:2020 Issue:17 Volume:10 Page:5925-5934
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Sudhakara Sneha¹²³⁴⁵^ORCID,Ramakrishnan Chandrasekaran⁶²³⁴⁵^ORCID,Gromiha M. Michael⁶²³⁴⁵,Chadha Anju¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Bioorganic Chemistry

2. Department of Biotechnology

3. Bhupat and Jyoti Mehta School of Biosciences

4. Indian Institute of Technology Madras

5. Chennai 600036

6. Protein Bioinformatics lab

Abstract

The quantum mechanics/molecular mechanics study of an (S) specific carbonyl reductase from C. parapsilosis ATCC 7330 showing a dual kinetic response for the reduction of ketones and α-ketoesters suggests different reaction mechanisms for the same.

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CY/D0CY01170C

Reference52 articles.

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3. Kinetic and Mechanistic Studies of a Novel Carbonyl Reductase Isolated from Candida Parapsilosis

4. Rationalization of enzyme enantioselectivity by active-site cubic-space models

5. How carbonyl reductases control stereoselectivity: Approaching the goal of rational design

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