Biocatalytic asymmetric Michael addition reaction ofl-arginine to fumarate for the green synthesis of N-(([(4S)-4-amino-4-carboxy-butyl]amino)iminomethyl)-l-aspartic acid lithium salt (l-argininosuccinic acid lithium salt)-Reference-Cited by-同舟云学术

Biocatalytic asymmetric Michael addition reaction ofl-arginine to fumarate for the green synthesis of N-(([(4S)-4-amino-4-carboxy-butyl]amino)iminomethyl)-l-aspartic acid lithium salt (l-argininosuccinic acid lithium salt)

Published:2017 Issue:77 Volume:7 Page:48952-48957
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Schoenenberger B.¹²³⁴,Wszolek A.⁵⁶⁷,Meier R.¹²³⁴,Brundiek H.⁵⁶⁷,Obkircher M.¹²³⁴,Wohlgemuth R.¹²³⁴^ORCID

Affiliation:

1. Sigma-Aldrich

2. Member of Merck Group

3. CH-9470 Buchs

4. Switzerland

5. Enzymicals

6. 17489 Greifswald

7. Germany

Abstract

The biocatalytic asymmetric Michael addition ofl-arginine to fumarate using argininosuccinate lyase (ASL) has enabled the synthesis of the key metabolitel-argininosuccinic acid lithium salt1for the first time, with excellent yield and purity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA10236D

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1. Ueber die Addition von Natriumacetessig- und Natriummalonsäureäthern zu den Aethern ungesättigter Säuren

2. Catalytic asymmetric synthesis with trans-chelating chiral diphosphine ligand TRAP: rhodium-catalyzed asymmetric Michael addition of .alpha.-cyano carboxylates

3. Catalytic Asymmetric Michael Reactions Promoted by a Lithium-Free Lanthanum-BINOL Complex

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