Enantioselective direct vinylogous Michael addition for constructing enantioenriched γ,γ-dialkyl substituted butyrolactams and octahydroindoles-Reference-Cited by-同舟云学术

Enantioselective direct vinylogous Michael addition for constructing enantioenriched γ,γ-dialkyl substituted butyrolactams and octahydroindoles

Published:2022 Issue:12 Volume:20 Page:2387-2391
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yan Jiahang¹,Zhang Wenting²,He Qiaoqiao¹,Hou Jun¹,Zeng Hongxin¹,Wei Hongbo¹^ORCID,Xie Weiqing¹²

Affiliation:

1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling 712100, Shaanxi, China

2. State Key Laboratory of Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, Shaanxi, China

Abstract

A nickel(ii)/chiral N,N′-dioxide catalyzed asymmetric direct vinylogous Michael addition of unsaturated butyrolactams enables synthesizing enantioenriched γ,γ-dialkyl substituted butyrolactams and octahydroindoles.

Funder

Scientific Startup Foundation for Doctors of Northwest A and F University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00112H

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