N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases-Reference-Cited by-同舟云学术

N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases

Published:2016 Issue:51 Volume:52 Page:7943-7946
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Santana A. G.¹²³⁴,Vadlamani G.⁵⁶⁷⁴,Mark B. L.⁵⁶⁷⁴,Withers S. G.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of British Columbia

3. Vancouver

4. Canada

5. Department of Microbiology

6. University of Manitoba

7. Winnipeg

Abstract

Mono-, di- and trisaccharide derivatives of 1,2-unsaturated N-acetyl-d-glucal have been synthesized and shown to function as tight-binding inhibitors/slow substrates of representative hexosaminidases.

Funder

Natural Sciences and Engineering Research Council of Canada

European Molecular Biology Organization

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC02520J

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