A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo-Reference-Cited by-同舟云学术

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Published:2008-06-29 Issue:8 Volume:4 Page:483-490
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Yuzwa Scott A,Macauley Matthew S,Heinonen Julia E,Shan Xiaoyang,Dennis Rebecca J,He Yuan,Whitworth Garrett E,Stubbs Keith A,McEachern Ernest J,Davies Gideon J,Vocadlo David J

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.96.pdf

Reference48 articles.

1. Braak, H., Braak, E., Grundke-Iqbal, I. & Iqbal, K. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci. Lett. 65, 351–355 (1986).

2. Lee, V.M., Goedert, M. & Trojanowski, J.Q. Neurodegenerative tauopathies. Annu. Rev. Neurosci. 24, 1121–1159 (2001).

3. Ksiezak-Reding, H., Liu, W.K. & Yen, S.H. Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments. Brain Res. 597, 209–219 (1992).

4. Schneider, A., Biernat, J., von Bergen, M., Mandelkow, E. & Mandelkow, E.M. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38, 3549–3558 (1999).

5. Sengupta, A. et al. Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch. Biochem. Biophys. 357, 299–309 (1998).

Cited by 583 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Optimization of bioactivities of solvent extracts of bark and heartwood of Pterocarpus marsupium and exploration of neuroprotective effect linking to the major Phytoconstituents;Industrial Crops and Products;2024-12

2. Exploring the Role of Unconventional Post-Translational Modifications in Cancer Diagnostics and Therapy;Current Protein & Peptide Science;2024-12

3. Insights into the role of glycosyltransferase in the targeted treatment of gastric cancer;Biomedicine & Pharmacotherapy;2024-09

4. Influence of O-GlcNAcylation on KGN cell function;Endocrine and Metabolic Science;2024-09

5. hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis;Nature Communications;2024-08-28