Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro and molecular docking studies-Reference-Cited by-同舟云学术

Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro and molecular docking studies

Published:2020 Issue:40 Volume:44 Page:17374-17381
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Ghanem Aml¹²³⁴⁵,Emara Hamdy A.⁶²³⁴⁵,Muawia Shaden¹²³⁴⁵,Abd El Maksoud Ahmed I.⁷²³⁴⁵,Al-Karmalawy Ahmed A.⁸⁹¹⁰¹¹⁵^ORCID,Elshal Mohamed F.¹²³⁴⁵

Affiliation:

1. Department of Molecular Biology

2. Genetic Engineering and Biotechnology Research Institute

3. University of Sadat City

4. Sadat City

5. Egypt

6. Department of Plant Biotechnology

7. Department of Industrial Biotechnology

8. Department of Pharmaceutical Medicinal Chemistry

9. Faculty of Pharmacy

10. Horus University-Egypt

11. New Damietta 34518

Abstract

Schematic diagram showing the pharmacophoric features of doxorubicin and tanshinone IIA as DNA intercalators, and their effects on cardiac tissues.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ04088F

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