Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds-Reference-Cited by-同舟云学术

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Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds

Published:2023 Issue:9 Volume:14 Page:1698-1703
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Christoff Rebecca M.¹,Al Bayer Mohammad¹,Soares da Costa Tatiana P.²,Perugini Matthew A.²,Abbott Belinda M.¹^ORCID

Affiliation:

1. Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia

2. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia

Abstract

The synthesis of the first low micromolar dimeric inhibitor of E. coli DHDPS is reported.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00044C

Reference33 articles.

1. The importance of being dimeric

2. Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example

3. Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen

4. Dimeric Approaches to Anti-Cancer Chemotherapeutics

5. Design of amidobenzimidazole STING receptor agonists with systemic activity

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