Design of amidobenzimidazole STING receptor agonists with systemic activity-Reference-Cited by-同舟云学术

Design of amidobenzimidazole STING receptor agonists with systemic activity

Published:2018-11-07 Issue:7736 Volume:564 Page:439-443
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Ramanjulu Joshi M.,Pesiridis G. Scott,Yang Jingsong,Concha Nestor,Singhaus Robert,Zhang Shu-Yun,Tran Jean-Luc,Moore Patrick,Lehmann Stephanie,Eberl H. Christian,Muelbaier Marcel,Schneck Jessica L.,Clemens Jim,Adam Michael,Mehlmann John,Romano Joseph,Morales Angel,Kang James,Leister Lara,Graybill Todd L.,Charnley Adam K.,Ye Guosen,Nevins Neysa,Behnia Kamelia,Wolf Amaya I.,Kasparcova Viera,Nurse Kelvin,Wang Liping,Puhl Ana C.,Li Yue,Klein Michael,Hopson Christopher B.,Guss Jeffrey,Bantscheff Marcus,Bergamini Giovanna,Reilly Michael A.,Lian Yiqian,Duffy Kevin J.,Adams Jerry,Foley Kevin P.,Gough Peter J.,Marquis Robert W.,Smothers James,Hoos Axel,Bertin John

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-018-0705-y.pdf

Reference24 articles.

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2. Li, T. & Chen, Z. J. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. J. Exp. Med. 215, 1287–1299 (2018).

3. Mullard, A. Can innate immune system targets turn up the heat on ‘cold’ tumours? Nat. Rev. Drug Discov. 17, 3–5 (2018).

4. Woo, S. R. et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41, 830–842 (2014).

5. Klarquist, J. et al. STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells. J. Immunol. 193, 6124–6134 (2014).

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