Discovery of hydrazide-based pyridazino[4,5-b]indole scaffold as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy-Reference-Cited by-同舟云学术

Discovery of hydrazide-based pyridazino[4,5-b]indole scaffold as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy

Published:2020 Issue:33 Volume:10 Page:19534-19541
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sarhan Ahmed A. M.¹²³⁴⁵^ORCID,Boraei Ahmed T. A.¹²⁶⁷⁵^ORCID,Barakat Assem¹⁸⁹¹⁰¹¹^ORCID,Nafie Mohamed S.¹²⁶⁷⁵^ORCID

Affiliation:

1. Chemistry Department

2. Faculty of Science

3. Arish University

4. Al-Arish 45511

5. Egypt

6. Suez Canal University

7. Ismailia 41522

8. College of Science

9. King Saud University

10. Riyadh 11451

11. Saudi Arabia

Abstract

The mono and dialkylation of pyridazino[4,5-b]indole with a set of alkylating agents were achieved. The synthesized pyridazino[4,5-b]indole hits have been evaluated and discovered as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA02798G

Reference34 articles.

1. Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy

2. Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics

3. Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy