Affiliation:
1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China 5 Yushan Road Qingdao 266003 China
2. Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology (QNLM) Qingdao 266237 China
Abstract
AbstractA novel [3+3] annulation reaction of 2‐alkenylindoles with hydrazonyl chlorides in the presence of base for the formation of pyridazino[4,5‐b]indoles was developed. This approach provided a convenient and efficient way to synthesize a series of functionalized pyridazino[4,5‐b]indoles derivatives. The method exhibited a broad substrate scope and provided the corresponding pyridazino[4,5‐b]indoles products with excellent yields.
Funder
Taishan Scholar Foundation of Shandong Province
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
National Key Research and Development Program of China