Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors

Author:

Bruel Amélie,Logé Cédric,Tauzia Marie-Ludivine de,Ravache Myriam,Le Guevel Rémy,Guillouzo Christiane,Lohier Jean-François,Oliveira Santos Jana Sopkova-de,Lozach Olivier,Meijer Laurent,Ruchaud Sandrine,Bénédetti Hélène,Robert Jean-Michel

Funder

Canceropôle Grand Ouest

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference28 articles.

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2. New 5H-pyridazino[4,5-b]indole derivates. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics;Monge;J. Med. Chem.,1991

3. Indoles and pyridazino[4,5-b]indoles as nonnucleoside analog inhibitors of HIV-1 reverse transcriptase;Font;Eur. J. Med. Chem.,1995

4. Synthesis and hypertensive activity of certain Mannich bases of 2-ethoxycarbonylindoles and 5H-pyridazino[4,5-b]indoles;El-Gendy;Arch. Pharm. Res.,2001

5. Y. Evanno, L. Dubois, M. Sevrin, F. Marguet, J. Froissant, R. Bartsch, C.Gille, 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapy, US 6,262,045 B1.

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