Acylation or phosphorylation of hydroxyurea unexpectedly takes place on N rather than on O, leading to the formation of amides instead of the expected esters-Reference-Cited by-同舟云学术

Acylation or phosphorylation of hydroxyurea unexpectedly takes place on N rather than on O, leading to the formation of amides instead of the expected esters

Published:2015 Issue:31 Volume:5 Page:24038-24043
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pariente-Cohen Natalie¹²³⁴,Weitman Michal¹²³⁴,Tania Nassdyuk¹²³⁴,Major Dan T.¹²³⁴,Gottlieb Hugo E.¹²³⁴,Hoz Shmaryahu¹²³⁴,Nudelman Abraham¹²³⁴

Affiliation:

1. Chemistry Department

2. Bar-Ilan University

3. Ramat Gan 52900

4. Israel

Abstract

Attempted acylation of the anticancer agent hydroxyurea (HU) with acyl chlorides or anhydrides led to acylation on the NH group rather than on the OH.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA01016K

Reference28 articles.

1. Novel Mutual Prodrug of Retinoic and Butyric Acids with Enhanced Anticancer Activity

2. Novel Prodrugs of Tegafur that Display Improved Anticancer Activity and Antiangiogenic Properties

3. AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines

4. A Mutual Prodrug Ester of GABA and Perphenazine Exhibits Antischizophrenic Efficacy with Diminished Extrapyramidal Effects

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