Neighboring phenolic group-activated gem-difluoroallylboration of imines for the catalyst-free synthesis of gem-difluorohomoallylamines-Reference-Cited by-同舟云学术

Neighboring phenolic group-activated gem-difluoroallylboration of imines for the catalyst-free synthesis of gem-difluorohomoallylamines

Published:2018 Issue:18 Volume:16 Page:3367-3371
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Xing¹²³⁴⁵,Zhang Feng⁶⁷⁸⁹,Zhou Yang¹²³⁴⁵,Huang Yi-Yong¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. School of Chemistry

3. Chemical Engineering and Life Science

4. Wuhan University of Technology

5. Wuhan 430070

6. College of Science

7. Hunan Agricultural University

8. Changsha 410128

9. P. R. China

Abstract

An unprecedented imine allylation with pinacol gem-difluoroallylborates for the synthesis of a wide range of racemic gem-difluorohomoallylamine derivatives under catalyst-free conditions was enabled by a neighboring phenolic group in an N-protecting group.

Funder

National Natural Science Foundation of China

Hunan Agricultural University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00541A

Reference72 articles.

1. China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

2. Recent Developments in Trifluoromethylation or Difluoroalkylation by Use of Difluorinated Phosphonium Salts

3. The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

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